1. From the Research Institute of Public Health (S.K., J.L., T.A.L., J.T.S.) and Department of Public Health and General Practice, University of Kuopio (J.T.S.); Research Institute of Exercise Medicine (J.L., T.A.L.), Kuopio; Department of Neurology (J.S.), University Hospital of Kuopio, Brain Research and Rehabilitation Centre Neuron, Kuopio; and Department of Clinical Physiology and Nuclear Medicine (R.R.), University Hospital of Kuopio and Research Institute of Exercise Medicine, Kuopio, Finland.