Malignant Hypertension Is Accompanied by Marked Alterations in Chylomicron Metabolism

Abstract

Abstract Malignant hypertension (MH) is a severe complication of untreated arterial hypertension that damages the vascular system. It is often accompanied by disturbances in lipid metabolism that could contribute to its pathophysiology. We examined chylomicron metabolism in MH patients using a triglyceride-rich emulsion known to mimic natural chylomicrons when injected into the bloodstream. The emulsion was labeled with [ 3 H]triolein and [ 14 C]cholesteryl oleate and injected intravenously into 15 normolipidemic MH patients aged 29 to 56 years (8 men) for comparison with 17 healthy control subjects. Consecutive plasma samples were taken at regular intervals during 1 hour for determination of the disappearance curves of the labels. The fractional clearance rate of the [ 3 H]triolein emulsion in MH patients was twice as small as that of control subjects (0.061±0.012 and 0.141±0.074 min −1 , respectively). On the other hand, [ 14 C]cholesteryl oleate fractional clearance rate was not statistically different in MH patients and control subjects (0.032±0.004 and 0.056±0.014 min −1 , respectively). These results indicate that in MH, lipolysis (measured by the fractional clearance rate of [ 3 H]triolein) is pronouncedly diminished, whereas the removal of the remnant particles (measured by the fractional clearance rate of [ 14 C]cholesteryl oleate) is not importantly affected. In conclusion, there is an alteration in the circulatory transport of dietary lipids that may be an important component in the vascular disease associated with MH.