Congenital Malformations of the Heart Associated with Splenic Agenesis

Author:

GILBERT ENID F.1,NISHIMURA KINSUKE1,WEDUM BERNICE G.1

Affiliation:

1. From the Department of Pathology of The Children's Hospital, Washington, D. C.

Abstract

This paper presents a theory for the cause of congenital malformations of the heart and other structures associated with absence of the spleen. A colmplete review of the literature and the data of the authors' 5 cases lead to this proposal: a lethal factor, possibly the product of a faulty ovulation, specifically affects the germinal bed of the mesoblastic surface of the coelom at an ovulatory age of 24 to 28 days.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference120 articles.

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1. Spleen;Bergman's Comprehensive Encyclopedia of Human Anatomic Variation;2016-05-06

2. A Canine Case of Partial Heterotaxia Detected by Radiography and Ultrasound.;Journal of Veterinary Medical Science;2000

3. Asplenia as a Cause of Sudden Unexpected Death in Childhood;The American Journal of Forensic Medicine and Pathology;1999-03

4. Asplenia syndrome: Insight into embryology through an analysis of cardiac and extracardiac anomalies;The American Journal of Cardiology;1994-03

5. Septicaemia and adrenal haemorrhage in congenital asplenia.;Archives of Disease in Childhood;1991-05-01

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