Effect of Ganglionic Blocking Agents Upon Blood Flow and Resistance in the Superior Mesenteric Artery of the Dog

Abstract

The response of the mesenteric vascular circuit of anesthetized dogs to a group of ganglionic blocking agents has been studied. The results demonstrate that these agents produce a decrease in blood pressure, blood flow and vasomotor activity of the mesenteric bed and either no change or a decrease in mesenteric resistance. When the perfusing pressure to the mesenteric artery was maintained at control levels an increase in flow with a concomitant decrease in mesenteric resistance followed the injection of the blocking agents. The present report presents experimental evidence that our preliminary report was in error.