Circulatory and Renal Effects Following Transfusion of Human Blood and its Components to Dogs

Abstract

The cardiovascular effects of the transfusion of human blood and of some of its components were studied in dogs. Human blood, hemoglobin, globin and red cell stroma produced significant circulatory depression. The reaction to stromal materials was considered to represent a combination of peripheral pooling and myocardial depression. The reactions to human hemoglobin and globin indicated primary vasoconstriction as the initial abnormality. The reaction to human blood, apparently, was a combination of the reactions to stroma and hemoglobin, with an anaphylactoid response after second blood transfusions.