1. From CNS Discovery, Pfizer Global Research and Development, Groton, Conn (F.S.M., D.J.C., A.H.G., V.G., P.A.S., W.M.W.); Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada (A.M.B.); and Neurogen Corporation, Branford, Conn (B.L.C.).