Affiliation:
1. From the Departments of Medicine, Clinical Biochemistry (R.A.H., P.W.C.), and Biochemistry (P.W.C.), St Michael’s Hospital, University of Toronto, Ontario, and School of Nursing, University of Victoria, British Columbia (J.H.B.), Canada.
Abstract
Abstract
We hypothesized that variation of nine candidate genes in lipoprotein metabolism would be associated with variation in fasting plasma lipoprotein variables in 718 Alberta Hutterites, a genetic isolate. We measured plasma lipids, lipoproteins, and apolipoproteins and analyzed DNA for genotypes of apolipoprotein (apo) B (
APOB
), paraoxonase (
PON
), lipoprotein lipase (
LPL
), VLDL receptor (
VLDLR
), apo CIII (
APOC3
), LDL receptor–related protein (
LRP
), hepatic lipase (
HL
), LDL receptor (
LDLR
), and apo E (
APOE
). Using a multivariate analysis, we found that (1) genotypes of
APOB
,
PON
,
LPL
,
LDLR
, and
APOE
were significantly associated with variation of plasma apo B–related traits; (2) genotypes of
PON
,
LPL
, and
APOC3
were significantly associated with variation in plasma triglycerides; and (3) genotypes of
VLDLR
,
APOC3
,
LDLR
, and
APOE
were significantly associated with variation in plasma apo AI and HDL cholesterol. Regression analysis showed that between 3.2% and 7.8% of the total variation in plasma lipoproteins was accounted for by variation in the candidate genes tested. The observations demonstrate a modest but significant genetic component of variation in plasma lipoprotein levels that is due to the candidate genes studied in this normolipemic human genetic isolate.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
74 articles.
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