Myosin Gene Expression and Cell Phenotypes in Vascular Smooth Muscle During Development, in Experimental Models, and in Vascular Disease-Reference-Cited by-同舟云学术

Myosin Gene Expression and Cell Phenotypes in Vascular Smooth Muscle During Development, in Experimental Models, and in Vascular Disease

Published:1997-07 Issue:7 Volume:17 Page:1210-1215
ISSN:1079-5642
Container-title:Arteriosclerosis, Thrombosis, and Vascular Biology
language:en
Short-container-title:ATVB

Author:

Sartore Saverio¹,Chiavegato Angela¹,Franch Rafaella¹,Faggin Elisabetta¹,Pauletto Paolo¹

Affiliation:

1. From the Departments of Biomedical Sciences (S.S., A.C., R.F.) and of Clinical and Experimental Medicine (E.F., P.P.), University of Padua, and the CNR Unit for Muscle Biology and Physiopathology (S.S.), Padua, Italy.

Abstract

Abstract In the aortic wall of mammalian species, the maturation phase of smooth muscle cell (SMC) lineage is characterized by two temporally correlated but opposite regulatory processes of gene expression: upregulation of SM type SM2 myosin isoform and downregulation of brain (myosin heavy chain B)- and platelet (myosin heavy chain A pla )-type nonmuscle myosins. Using the myosin isoform approach to study vascular SMC biology, we have shown (1) a marked SMC heterogeneity in adult arterial vessels, ie, coexistence of an “immature” and a fully differentiated SMC population; and (2) the propensity of the immature type SMC population to be activated in experimental models and human vascular diseases that are characterized by proliferation and migration of medial SMCs into the subendothelial space.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.17.7.1210

Reference42 articles.

1. Regulation of differentiation of vascular smooth muscle cells

2. Myosin Isoform Expression in Smooth Muscle Cells during Physiological and Pathological Vascular Remodeling

3. Myosin isoforms in smooth muscle: how may they affect function and structure?

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