Longitudinal Changes in Health‐Related Quality of Life in Patients With Atrial Fibrillation-Reference-Cited by-同舟云学术

Longitudinal Changes in Health‐Related Quality of Life in Patients With Atrial Fibrillation

Published:2023-11-07 Issue:21 Volume:12 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

Foster‐Witassek Fabienne¹^ORCID,Aebersold Helena¹^ORCID,Aeschbacher Stefanie²³^ORCID,Ammann Peter⁴,Beer Jürg H.⁵⁶^ORCID,Blozik Eva⁷^ORCID,Bonati Leo H.⁸⁹^ORCID,Cattaneo Mattia¹⁰,Coslovsky Michael³¹¹^ORCID,Felder Stefan¹²^ORCID,Moschovitis Giorgio¹⁰^ORCID,Müller Andreas¹³^ORCID,Netzer Seraina¹⁴¹⁵,Paladini Rebecca E.²³^ORCID,Reichlin Tobias¹⁶^ORCID,Rodondi Nicolas¹⁴¹⁵^ORCID,Stauber Annina¹³^ORCID,Sticherling Christian²³^ORCID,Szucs Thomas¹⁷^ORCID,Conen David¹⁸^ORCID,Kühne Michael²³^ORCID,Osswald Stefan²³^ORCID,Serra‐Burriel Miquel¹^ORCID,Schwenkglenks Matthias¹¹⁹^ORCID,

Affiliation:

1. Epidemiology, Biostatistics and Prevention Institute University of Zurich Zurich Switzerland

2. Cardiology Division, Department of Medicine University Hospital Basel Basel Switzerland

3. Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland

4. Department of Cardiology Cantonal Hospital of St. Gallen St. Gallen Switzerland

5. Department of Medicine Cantonal Hospital of Baden Baden Switzerland

6. Center for Molecular Cardiology University of Zurich Zurich Switzerland

7. Institute of Primary Care University of Zurich Zurich Switzerland

8. Department of Neurology University Hospital Basel Basel Switzerland

9. Research Department Reha Rheinfelden Rheinfelden Switzerland

10. Division of Cardiology, Ente Ospedaliero Cantonale, Istituto Cardiocentro Ticino Ospedale Regionale di Lugano Lugano Switzerland

11. Department of Clinical Research University of Basel, University Hospital Basel Basel Switzerland

12. Faculty of Business and Economics University of Basel Basel Switzerland

13. Department of Cardiology Triemli Hospital Zurich Zurich Switzerland

14. Institute of Primary Health Care University of Bern Bern Switzerland

15. Department of General Internal Medicine, Inselspital Bern University Hospital, University of Bern Bern Switzerland

16. Department of Cardiology, Inselspital Bern University Hospital, University of Bern Bern Switzerland

17. Institute of Pharmaceutical Medicine University of Basel Basel Switzerland

18. Population Health Research Institute McMaster University Hamilton Ontario Canada

19. Health Economics Facility, Department of Public Health University of Basel Basel Switzerland

Abstract

Background Optimizing health‐related quality of life (HRQoL) is an important aim of atrial fibrillation (AF) treatment. Little is known about patients' long‐term HRQoL trajectories and the impact of patient and disease characteristics. The aim of this study was to describe HRQoL trajectories in an observational AF study population and in clusters of patients with similar patient and disease characteristics. Methods and Results We used 5‐year follow‐up data from the Swiss–Atrial Fibrillation prospective cohort, which enrolled 2415 patients with prevalent AF from 2014 to 2017. HRQoL data, collected yearly, comprised EuroQoL‐5 dimension utilities and EuroQoL visual analog scale scores. Patient clusters with similar characteristics at enrollment were identified using hierarchical clustering. HRQoL trajectories were analyzed descriptively and with inverse probability‐weighted regressions. Effects of postbaseline clinical events were additionally assessed using time‐shifted event variables. Among 2412 (99.9%) patients with available baseline HRQoL, 3 clusters of patients with AF were identified, which we characterized as follows: “cardiovascular dominated,” “isolated symptomatic,” and “severely morbid without cardiovascular disease.” Utilities and EuroQoL visual analog scale scores remained stable over time for the full population and the clusters; isolated symptomatic patients showed higher levels of HRQoL. Utilities were reduced after occurrences of stroke, hospitalization for heart failure, and bleeding, by −0.12 (95% CI, −0.18 to −0.06), −0.10 (95% CI, −0.13 to −0.08), and −0.06 (95% CI, −0.08 to −0.04), respectively, on a 0 to 1 utility scale. Utility of surviving patients returned to preevent levels 4 years after heart failure hospitalization; 3 years after bleeding; and 1 year after stroke. Conclusions In patients with prevalent AF, HRQoL was stable over time, irrespective of baseline patient characteristics. Clinical events of hospitalization for heart failure, stroke, and bleeding had only a temporary effect on HRQoL.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference27 articles.

1. Epidemiology of Atrial Fibrillation in the 21st Century

2. Atrial fibrillation: the current epidemic;Morillo CA;J Geriatr Cardiol,2017

3. Quality of life after atrial fibrillation ablation: measuring the most important end-point

4. Quality of life in older people with atrial fibrillation