Affiliation:
1. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Dallas Dallas TX USA
2. University of Texas Southwestern Medical Center Dallas TX USA
3. Department of Medicine and Biosystemic Science, Hematology, Oncology, and Cardiovascular Medicine, School of Medicine Kyushu University Fukuoka Japan
Abstract
Background
Moderate intensity exercise training (MIT) is safe and effective for patients with hypertrophic cardiomyopathy, yet the efficacy of high intensity training (HIT) remains unknown. This study aimed to compare the efficacy of HIT compared with MIT in patients with hypertrophic cardiomyopathy.
Methods and Results
Patients with hypertrophic cardiomyopathy were randomized to either 5 months of MIT, or 1 month of MIT followed by 4 months of progressive HIT. Peak oxygen uptake (V˙O
2
; Douglas bags), cardiac output (acetylene rebreathing), and arteriovenous oxygen difference (Fick equation) were measured before and after training. Left ventricular outflow gradient and volumes were measured by echocardiography. Fifteen patients completed training (MIT, n=8, age 52±7 years; HIT, n=7, age 42±8 years). Both HIT and MIT improved peak V˙O
2
by 1.3 mL/kg per min (
P
=0.009). HIT (+1.5 mL/kg per min) had a slightly greater effect than MIT (+1.1 mL/kg per min) but with no statistical difference (group×exercise
P
=0.628). A greater augmentation of arteriovenous oxygen difference occurred with exercise (Δ1.6 mL/100 mL
P
=0.005). HIT increased left ventricular end‐diastolic volume (+17 mL, group×exercise
P
=0.015) compared with MIT. No serious arrhythmias or adverse cardiac events occurred.
Conclusions
This randomized trial of exercise training in patients with hypertrophic cardiomyopathy demonstrated that both HIT and MIT improved fitness without clear superiority of either. Although the study was underpowered for safety outcomes, no serious adverse events occurred. Exercise training resulted in salutary peripheral and cardiac adaptations.
Registration
URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03335332.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
1 articles.
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