Affiliation:
1. Department of Medical Genetics and the Department of Cardiology, Children's Hospital of Winnipeg, and the Department of Pediatrics, University of Manitoba Winnipeg, Manitoba, Canada
Abstract
Three presumptive cardiac tissues from aborted human embryos which ranged in length from 2 mm to 4 mm and in age from 53 days to 71 days were maintained in culture beating rhythmically for 18-88 days. Medium renewal, temperature increases (from 31° to 38°C), and pH increases (from 6.92 to 7.75) raised the pulsation rate. Excess potassium stopped the pulsation. Sympathomimetic drugs increased the pulsation rate, and this action was blocked by the beta-receptor inhibitor, propranolol, suggesting the presence of functioning beta-receptor sites in the heart cells by the end of the second month of development.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference14 articles.
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