Auricular Fibrillation Induced and Maintained in Animals by Acetylcholine or Vagal Stimulation

Author:

LOOMIS TED A.1,KROP STEPHEN1

Affiliation:

1. Physiology Division, Chemical Corps Medical Laboratories, Army Chemical Center, Maryland

Abstract

Animals pretreated with appropriate doses of anticholinesterase agents develop auricular flutter and fibrillation following injection of acetylcholine or vagal stimulation. Depression of normal sinoauricular nodal function facilitates induction of fibrillation. During fibrillation, additional injections of acetylcholine, or vagal stimulation, increase the rate of fibrillation. Atropine in small doses reverts the fibrillation to normal sinus rhythm.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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