Action of Dinitrophenol and Lanatoside C on the Canine Heart-Lung Preparation

Abstract

Dinitrophenol (DNP) induces failure of the canine heart-lung-preparation and increases specifically its O 2 -consumption. Lanatoside C compensates this failure as long as the degree of dinitrophenol poisoning is moderate and the O 2 -supply sufficiently ample. This cardiac glycoside does not influence the metabolic action of dinitrophenol, i.e. the increased O 2 -consumption, nor does it counteract the failure due to a large degree of dinitrophenol poisoning. From these findings the mechanism of action of Lanatoside C is discussed.