Affiliation:
1. University of California, San Francisco, San Francisco, CA
2. Washington University School of Medicine, St. Louis, MO
3. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR
4. University of Washington and Group Health Research Institute, Seattle, WA
Abstract
Background
Premature cardiac contractions are associated with increased morbidity and mortality. Though experts associate premature atrial contractions (
PAC
s) and premature ventricular contractions (
PVC
s) with caffeine, there are no data to support this relationship in the general population. As certain caffeinated products may have cardiovascular benefits, recommendations against them may be detrimental.
Methods and Results
We studied Cardiovascular Health Study participants with a baseline food frequency assessment, 24‐hour ambulatory electrocardiography (Holter) monitoring, and without persistent atrial fibrillation. Frequencies of habitual coffee, tea, and chocolate consumption were assessed using a picture‐sort food frequency survey. The main outcomes were
PAC
s/h and
PVC
s/hour. Among 1388 participants (46% male, mean age 72 years), 840 (61%) consumed ≥1 caffeinated product per day. The median numbers of
PAC
s and
PVC
s/h and interquartile ranges were 3 (1–12) and 1 (0–7), respectively. There were no differences in the number of
PAC
s or
PVC
s/h across levels of coffee, tea, and chocolate consumption. After adjustment for potential confounders, more frequent consumption of these products was not associated with ectopy. In examining combined dietary intake of coffee, tea, and chocolate as a continuous measure, no relationships were observed after multivariable adjustment: 0.48% fewer
PAC
s/h (95%
CI
−4.60 to 3.64) and 2.87% fewer
PVC
s/h (95%
CI
−8.18 to 2.43) per 1‐serving/week increase in consumption.
Conclusions
In the largest study to evaluate dietary patterns and quantify cardiac ectopy using 24‐hour Holter monitoring, we found no relationship between chronic consumption of caffeinated products and ectopy.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
39 articles.
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