1. From the Inserm, UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Caen, France (T.G., C.G., A.M., V.A., M.R., E.E., D.V., M.G.); and Department of Neurosurgery (T.G., E.E.), Department of Anesthesiology and Critical Care Medicine (M.H.), and Biostatistics and Clinical Research Unit (M.R.), Caen University Hospital, Caen, France.