1. From the Department of Neurology (M.S., Y.F., R.O., M.I., R.T., H.T.), Graduate School of Medicine, and Horizontal Brain Research Organization (N.Y., T.M.), Kyoto University, Sakyo-ku, Kyoto, Japan; and the Institute for Health and Ageing (R.N.K.), University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle-upon-Tyne, UK.