Inflammation and Stroke Risk: A New Target for Prevention-Reference-Cited by-同舟云学术

Inflammation and Stroke Risk: A New Target for Prevention

Published:2021-08 Issue:8 Volume:52 Page:2697-2706
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Kelly Peter J.¹²^ORCID,Lemmens Robin³⁴⁵^ORCID,Tsivgoulis Georgios⁶^ORCID

Affiliation:

1. Stroke Service, Mater University Hospital and University College Dublin, Ireland (P.J.K.).

2. Health Research Board Stroke Clinical Trials Network Ireland (P.J.K.).

3. KU Leuven – University of Leuven, Department of Neurosciences, Experimental Neurology, Belgium (R.L.).

4. VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium (R.L.).

5. Department of Neurology, University Hospitals Leuven, Belgium (R.L.).

6. Second Department of Neurology, “Attikon” University Hospital, National & Kapodistrian University of Athens, Greece (G.T.).

Abstract

New therapeutic approaches are required for secondary prevention of residual vascular risk after stroke. Diverse sources of evidence support a causal role for inflammation in the pathogenesis of stroke. Randomized controlled trials of anti-inflammatory agents have reported benefit for secondary prevention in patients with coronary disease. We review the data from observational studies supporting a role for inflammation in pathogenesis of stroke, overview randomized controlled trials of anti-inflammatory therapy in cardiac disease and discuss the potential implications for stroke prevention therapy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

Link

https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.121.034388

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