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The ARUBA Trial

Published:2010-08 Issue:8 Volume:41 Page:
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Mohr J.P.¹,Moskowitz Alan J.¹,Stapf Christian¹,Hartmann Andreas¹,Lord Karen¹,Marshall Steven M.¹,Mast Henning¹,Moquete Ellen¹,Moy Claudia Scala¹,Parides Michael¹,Pile-Spellman John¹,Salman Rustam Al-Shahi¹,Weinberg Alan¹,Young William L.¹,Estevez Alejandrina¹,Kureshi Inam¹,Brisman Jonathan L.¹

Affiliation:

1. From Columbia University College of Physicians and Surgeons (J.P.M., K.L., J.P.-S.), New York, NY; Doris & Stanley Tananbaum Stroke Center (J.P.M.), Neurological Institute, New York, NY; Mt. Sinai School of Medicine (A.F.M., E.M., M.P., A.E., A.W.), New York, NY; Hôpital Lariboisière (C.S.), Paris, France; Klinikum Frankfurt (Oder) (A.H.), Frankfurt, Germany; Columbia University (K.L.), New York, NY; Columbia University (S.M.M.), New York, NY; Klinik-im-Park (H.M.), Zurich, Switzerland;...

Abstract

Background and Purpose— Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review— Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions— ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

Link

https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.110.580274

Reference51 articles.

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2. Incidence of Adult Brain Arteriovenous Malformation Hemorrhage in a Prospective Population-Based Stroke Survey

3. The New York Islands AVM Study

4. Prospective, Population-Based Detection of Intracranial Vascular Malformations in Adults

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