Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise-Reference-Cited by-同舟云学术

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Published:2024-04 Issue:4 Volume:55 Page:812-821
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Dao Elizabeth¹²³^ORCID,Barha Cindy K.⁴⁵^ORCID,Zou Jammy⁶²³⁷^ORCID,Wei Nathan⁶²³⁷^ORCID,Liu-Ambrose Teresa⁶²³⁷^ORCID

Affiliation:

1. Department of Radiology (E.D.)

2. Department of Physical Therapy, Aging, Mobility, and Cognitive Health Laboratory (E.D., J.Z., N.W., T.L.-A.), Faculty of Medicine, The University of British Columbia, Vancouver, Canada

3. Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, Canada (E.D., J.Z., N.W., T.L.-A.).

4. Faculty of Kinesiology (C.K.B.), University of Calgary, AB, Canada.

5. Hotchkiss Brain Institute (C.K.B.), University of Calgary, AB, Canada.

6. Department of Physical Therapy (J.Z., N.W., T.L.-A.)

7. Centre for Aging SMART at Vancouver Coastal Health, Vancouver Coastal Health Research Institute, BC, Canada (J.Z., N.W., T.L.-A.).

Abstract

Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Exercise has the potential to prevent and mitigate CSVD-related brain damage and improve cognitive function. Mechanistic pathways underlying the neurocognitive benefits of exercise include the control of vascular risk factors, improving endothelial function, and upregulating exerkines. Notably, the therapeutic efficacy of exercise may vary by exercise type (ie, aerobic versus resistance training) and biological sex; thus, studies designed specifically to examine these moderating factors within a CSVD context are needed. Furthermore, future research should prioritize resistance training interventions, given their tremendous therapeutic potential. Addressing these knowledge gaps will help us refine exercise recommendations to maximize their therapeutic impact in the prevention and mitigation of CSVD.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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