Global, Regional, and National Burdens of Stroke in Children and Adolescents From 1990 to 2019: A Population-Based Study-Reference-Cited by-同舟云学术

Global, Regional, and National Burdens of Stroke in Children and Adolescents From 1990 to 2019: A Population-Based Study

Published:2024-06 Issue:6 Volume:55 Page:1543-1553
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Sun Hao¹^ORCID,Ma Bing¹,Jin Chenye²,Li Zhenning³,Song Xinying⁴,Bu Yifan⁵^ORCID,Liu Tingting⁶,Han Xu⁷,Yang Xue⁸^ORCID,Yang Kaijie⁸,Xu Dongchu⁹^ORCID,Zhang Jing¹⁰,Li Yongze⁸^ORCID

Affiliation:

1. Department of Clinical Epidemiology and Evidence-Based Medicine (H.S., B.M.), The First Hospital of China Medical University, Shenyang.

2. Department of Rheumatology and Immunology (C.J.), The First Hospital of China Medical University, Shenyang.

3. Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, Liaoning Province Key Laboratory of Oral Disease (Z.L.).

4. Department of Radiology, Shengjing Hospital of China Medical University, Shenyang (X.S.).

5. Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center, Boston, MA (Y.B.).

6. Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China (T.L.).

7. Department of Obstetrics (X.H.), The First Hospital of China Medical University, Shenyang.

8. Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Disease (X.Y., K.Y., Y.L.), The First Hospital of China Medical University, Shenyang.

9. Harvard Medical School, Boston, MA (D.X.).

10. School of Public Health, Shenzhen University Medical School, China (J.Z.).

Abstract

BACKGROUND: Stroke is one of the leading causes of death among children, yet evidence on stroke incidence and prognosis in this population is largely neglected worldwide. The aim of this study was to estimate the latest burden of childhood stroke, as well as trends, risk factors, and inequalities from 1990 to 2019, at the global, regional, and national levels. METHODS: The Global Burden of Disease 2019 study was utilized to evaluate the prevalence, incidence, years lived with disability, years of life lost (YLLs), and average annual percentage changes in stroke among populations aged 0 to 19 years from 1990 to 2019. RESULTS: The global age–standardized incidence of stroke increased (average annual percentage change, 0.15% [95% uncertainty interval, 0.09%–0.21%]), while YLLs decreased substantially (average annual percentage change, −3.33% [95% uncertainty interval, −3.38% to −3.28%]) among children and adolescents between 1990 and 2019. Ischemic stroke accounted for 70% of incident cases, and intracerebral hemorrhage accounted for 63% of YLLs. Children under 5 years of age had the highest incidence of ischemic stroke, while adolescents aged 15 to 19 years had the highest incidence of hemorrhagic stroke. In 2019, low-income and middle-income countries were responsible for 84% of incident cases and 93% of YLLs due to childhood stroke. High-sociodemographic index countries had a reduction in YLLs due to stroke that was more than twice as fast as that of low-income and middle-income. CONCLUSIONS: Globally, the burden of childhood stroke continues to increase, especially among females, children aged <5 years, and low-sociodemographic index countries, such as sub-Saharan Africa. The burden of childhood stroke is likely undergoing a significant transition from being fatal to causing disability. Global public health policies and the deployment of health resources need to respond rapidly and actively to this shift.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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