Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study-Reference-Cited by-同舟云学术

Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study

Published:2023-05 Issue:5 Volume:54 Page:1303-1311
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Sandvig Heidi Vihovde¹²^ORCID,Aam Stina²³^ORCID,Alme Katinka Nordheim⁴^ORCID,Askim Torunn²^ORCID,Beyer Mona K.⁵⁶^ORCID,Ellekjær Hanne²⁷,Ihle-Hansen Hege⁸^ORCID,Lydersen Stian⁹^ORCID,Mollnes Tom Eirik¹⁰¹¹¹²,Munthe-Kaas Ragnhild¹³^ORCID,Næss Halvor¹⁴¹⁵¹⁶^ORCID,Saltvedt Ingvild²³^ORCID,Seljeseth Yngve Müller¹⁷^ORCID,Thingstad Pernille²^ORCID,Wethal Torgeir²⁷,Knapskog Anne-Brita¹⁸^ORCID

Affiliation:

1. Department of Medicine, Kristiansund Hospital, Møre og Romsdal Hospital Trust, Norway (H.V.S.).

2. Department of Neuromedicine and Movement Science (H.V.S., S.A., T.A., H.E., I.S., P.T., T.W.), NTNU – Norwegian University of Science and Technology, Trondheim.

3. Department of Geriatric Medicine, Clinic of Medicine, St. Olavs Hospital (S.A., I.S.), Trondheim University Hospital, Norway.

4. Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway (K.N.A.).

5. Division of Radiology and Nuclear Medicine (M.K.B.), Oslo University Hospital, Norway.

6. Institute of Clinical Medicine, University of Oslo, Norway (M.K.B.).

7. Department of Medicine, Stroke Unit (H.E., T.W.), Trondheim University Hospital, Norway.

8. Oslo Stroke Unit, Department of Neurology (H.I.-H.), Oslo University Hospital, Norway.

9. Department of Mental Health (S.L.), NTNU – Norwegian University of Science and Technology, Trondheim.

10. Faculty of Medicine and Health Science, and Centre of Molecular Inflammation Research (T.E.M.), NTNU – Norwegian University of Science and Technology, Trondheim.

11. Department of Immunology, Oslo University Hospital and University of Oslo, Norway (T.E.M.).

12. Research Laboratory, Nordland Hospital, Bodø, Norway (T.E.M.).

13. Department of Medicine, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway (R.M.-K.).

14. Department of Neurology, Haukeland University Hospital, Bergen, Norway (H.N.).

15. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway (H.N.).

16. Institute of Clinical Medicine (K1), University of Bergen, Norway (H.N.).

17. Medical Department, Ålesund Hospital, Møre og Romsdal Hospital Trust, Norway (Y.M.S.).

18. Department of Geriatric Medicine (A.-B.K.), Oslo University Hospital, Norway.

Abstract

Background: Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment. Methods: The Nor-COAST study (Norwegian Cognitive Impairment After Stroke) is a prospective observational multicenter cohort study, including patients hospitalized with acute stroke between 2015 and 2017. Inflammatory biomarkers, including the TCC (terminal C5b-9 complement complex) and 20 cytokines, were analyzed in plasma, collected at baseline, 3-, and 18 months poststroke, using ELISA and a multiplex assay. Global cognitive outcome was assessed with the Montreal Cognitive Assessment (MoCA) scale. We investigated the associations between plasma inflammatory biomarkers at baseline and MoCA score at 3-, 18-, and 36-month follow-ups; the associations between inflammatory biomarkers at 3 months and MoCA score at 18- and 36-month follow-ups; and the association between these biomarkers at 18 months and MoCA score at 36-month follow-up. We used mixed linear regression adjusted for age and sex. Results: We included 455 survivors of ischemic stroke. Higher concentrations of 7 baseline biomarkers were significantly associated with lower MoCA score at 36 months; TCC, IL (interleukin)-6, and MIP (macrophage inflammatory protein)-1α were associated with MoCA at 3, 18, and 36 months ( P <0.01). No biomarker at 3 months was significantly associated with MoCA score at either 18 or 36 months, whereas higher concentrations of 3 biomarkers at 18 months were associated with lower MoCA score at 36 months ( P <0.01). TCC at baseline and IL-6 and MIP-1α measured both at baseline and 18 months were particularly strongly associated with MoCA ( P <0.01). Conclusions: Higher concentrations of plasma inflammatory biomarkers were associated with lower MoCA scores up to 36 months poststroke. This was most pronounced for inflammatory biomarkers measured in the acute phase following stroke. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02650531.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

Reference46 articles.

1. Systematic Review and Meta-Analysis of Prevalence in Post-Stroke Neurocognitive Disorders in Hospital-Based Studies

2. Impact of different methods defining post‐stroke neurocognitive disorder: The Nor‐COAST study

3. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study

4. Early-onset and delayed-onset poststroke dementia — revisiting the mechanisms

5. Amyloid Burden, Neuroinflammation, and Links to Cognitive Decline After Ischemic Stroke

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