Thrombectomy in Extensive Stroke May Not Be Beneficial and Is Associated With Increased Risk for Hemorrhage
Author:
Meyer Lukas1ORCID, Bechstein Matthias1ORCID, Bester Maxim1ORCID, Hanning Uta1, Brekenfeld Caspar1, Flottmann Fabian1, Kniep Helge1ORCID, van Horn Noel1ORCID, Deb-Chatterji Milani2ORCID, Thomalla Götz2, Sporns Peter13, Yeo Leonard Leong-Litt45, Tan Benjamin Yong-Qiang45, Gopinathan Anil65, Kastrup Andreas7, Politi Maria8, Papanagiotou Panagiotis89, Kemmling André1011, Fiehler Jens1ORCID, Broocks Gabriel1, Wunderlich Silke, Boeckh-Behrens Tobias, Reich Arno, Wiesmann Martin, Ernemann Ulrike, Hauser Till-Karsten, Siebert Eberhard, Nolte Christian, Zweynert Sarah, Bohner Georg, Ludolph Alexander, Henn Karl-Heinz, Pfeilschifter Waltraud, Wagner Marlis, Röther Joachim, Eckert Bernd, Berrouschot Jörg, Bormann Albrecht, Alegiani Anna, Hattingen Elke, Petzold Gabor, Thonke Sven, Bangard Christopher, Kraemer Christoffer, Dichgans Martin, Wollenweber Frank, Kellert Lars, Dorn Franziska, Herzberg Moriz, Psychogios Marios, Liman Jan, Petersen Martina, Stögbauer Florian, Kraft Peter, Pham Mirko, Braun Michael, Hamann Gerhard F., Gröschel Klaus, Uphaus Timo, Limmroth Volker,
Affiliation:
1. Department of Diagnostic and Interventional Neuroradiology (L.M., M. Bechstein, M. Bester, U.H., C.B., F.F., H.K., N.v.H., P.S., J.F., G.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 2. Department of Neurology (M.D.-C., G.T.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 3. Department of Diagnostic and Interventional Neuroradiology, University Hospital Basel, Switzerland (P.S.). 4. Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore (L.L.-L.Y., B.Y.-Q.T.). 5. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore (L.L.-L.Y., B.Y.-Q.T., A.G.). 6. Division of Interventional Radiology, Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore (A.G.). 7. Department of Neurology, Hospital Bremen-Mitte, Bremen, Germany (A. Kastrup). 8. Department of Diagnostic and Interventional Neuroradiology, Hospital Bremen-Mitte, Germany (M.P., P.P.). 9. Areteion University Hospital, National and Kapodistrian University of Athens, Greece (P.P.). 10. Department of Neuroradiology, Westpfalz-Klinikum, Kaiserslautern, Germany (A. Kemmling). 11. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Marburg, Marburg University, Germany (A. Kemmling).
Abstract
Background and Purpose:
This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared with best medical treatment.
Methods:
This retrospective, multicenter study compares EVT and best medical treatment for computed tomography (CT)–based selection of patients with extensive baseline infarcts (Alberta Stroke Program Early CT Score ≤5) attributed to anterior circulation stroke. Patients were selected from the German Stroke Registry and 3 tertiary stroke centers. Primary functional end points were rates of good (modified Rankin Scale score of ≤3) and very poor outcome (modified Rankin Scale score of ≥5) at 90 days. Secondary safety end point was the occurrence of symptomatic intracerebral hemorrhage. Angiographic outcome was evaluated with the modified Thrombolysis in Cerebral Infarction Scale.
Results:
After 1:1 pair matching, a total of 248 patients were compared by treatment arm. Good functional outcome was observed in 27.4% in the EVT group, and in 25% in the best medical treatment group (
P
=0.665). Advanced age (adjusted odds ratio, 1.08 [95% CI, 1.05–1.10],
P
<0.001) and symptomatic intracerebral hemorrhage (adjusted odds ratio, 6.35 [95% CI, 2.08–19.35],
P
<0.001) were independently associated with very poor outcome. Mortality (43.5% versus 28.9%,
P
=0.025) and symptomatic intracerebral hemorrhage (16.1% versus 5.6%,
P
=0.008) were significantly higher in the EVT group. The lowest rates of good functional outcome (≈15%) were observed in groups of failed and partial recanalization (modified Thrombolysis in Cerebral Infarction Scale score of 0/1–2a), whereas patients with complete recanalization (modified Thrombolysis in Cerebral Infarction Scale score of 3) with recanalization attempts ≤2 benefitted the most (modified Rankin Scale score of ≤3:42.3%,
P
=0.074) compared with best medical treatment.
Conclusions:
In daily clinical practice, EVT for CT–based selected patients with low Alberta Stroke Program Early CT Score anterior circulation stroke may not be beneficial and is associated with increased risk for hemorrhage and mortality, especially in the elderly. However, first- or second-pass complete recanalization seems to reveal a clinical benefit of EVT highlighting the vulnerability of the low Alberta Stroke Program Early CT Score subgroup.
REGISTRATION:
URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03356392.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Reference46 articles.
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