Cerebral Amyloid Angiopathy and the Fibrinolytic System: Is Plasmin a Therapeutic Target?-Reference-Cited by-同舟云学术

Cerebral Amyloid Angiopathy and the Fibrinolytic System: Is Plasmin a Therapeutic Target?

Published:2021-08 Issue:8 Volume:52 Page:2707-2714
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Mutimer Chloe A.¹,Keragala Charithani B.²,Markus Hugh S.³^ORCID,Werring David J.⁴^ORCID,Cloud Geoffrey C.¹⁵^ORCID,Medcalf Robert L.²^ORCID

Affiliation:

1. Department of Neurology, Alfred Hospital, Melbourne, Australia (C.A.M., G.C.C.).

2. Australian Centre for Blood Diseases (C.B.K., R.L.M.), Monash University, Melbourne, Australia.

3. Stroke Research Group, Department of Clinical Neuroscience, University of Cambridge, United Kingdom (H.S.M.).

4. Stroke Research Centre, Queen Square Institute of Neurology, London, United Kingdom (D.J.W.).

5. Department of Clinical Neuroscience, Central Clinical School (G.C.C.), Monash University, Melbourne, Australia.

Abstract

Cerebral amyloid angiopathy is a devastating cause of intracerebral hemorrhage for which there is no specific secondary stroke prevention treatment. Here we review the current literature regarding cerebral amyloid angiopathy pathophysiology and treatment, as well as what is known of the fibrinolytic pathway and its interaction with amyloid. We postulate that tranexamic acid is a potential secondary stroke prevention treatment agent in sporadic cerebral amyloid angiopathy, although further research is required.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

Link

https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.120.033107

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