Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging

Author:

Jian Xueqiu1,Satizabal Claudia L.2,Smith Albert V.3,Wittfeld Katharina4,Bis Joshua C.5,Smith Jennifer A.6,Hsu Fang-Chi7,Nho Kwangsik8,Hofer Edith9,Hagenaars Saskia P.10,Nyquist Paul A.11,Mishra Aniket12,Adams Hieab H.H.13,Li Shuo14,Teumer Alexander15,Zhao Wei6,Freedman Barry I.16,Saba Yasaman17,Yanek Lisa R.18,Chauhan Ganesh12,van Buchem Mark A.19,Cushman Mary20,Royle Natalie A.10,Bryan R. Nick21,Niessen Wiro J.2223,Windham Beverly G.,DeStefano Anita L.14,Habes Mohamad24,Heckbert Susan R.5,Palmer Nicholette D.25,Lewis Cora E.26,Eiriksdottir Gudny3,Maillard Pauline27,Mathias Rasika A.18,Homuth Georg28,Valdés-Hernández Maria del C.10,Divers Jasmin7,Beiser Alexa S.14,Langner Sönke29,Rice Kenneth M.30,Bastin Mark E.10,Yang Qiong14,Maldjian Joseph A.31,Starr John M.10,Sidney Stephen32,Risacher Shannon L.8,Uitterlinden André G.33,Gudnason Vilmundur G.3,Nauck Matthias34,Rotter Jerome I.35,Schreiner Pamela J.36,Boerwinkle Eric37,van Duijn Cornelia M.13,Mazoyer Bernard38,von Sarnowski Bettina39,Gottesman Rebecca F.11,Levy Daniel40,Sigurdsson Sigurdur3,Vernooij Meike W.41,Turner Stephen T.42,Schmidt Reinhold9,Wardlaw Joanna M.10,Psaty Bruce M.5,Mosley Thomas H.,DeCarli Charles S.27,Saykin Andrew J.,Bowden Donald W.25,Becker Diane M.18,Deary Ian J.10,Schmidt Helena17,Kardia Sharon L.R.6,Ikram M. Arfan43,Debette Stéphanie12,Grabe Hans J.44,Longstreth W.T.45,Seshadri Sudha2,Launer Lenore J.46,Fornage Myriam1,

Affiliation:

1. From the Institute of Molecular Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (M.F., X.J.)

2. Department of Neurology, Boston University School of Medicine, MA (C.L.S., S. Seshadri)

3. Icelandic Heart Association, Kópavogur, Iceland (A.V.S., G.E., S. Sigurdsson, V.G.G.)

4. German Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Germany (K.W.)

5. Cardiovascular Health Research Unit (B.M.P., J.C.B., S.R.H.)

6. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (J.A.S., S.L.R.K., W.Z.)

7. Division of Public Health Sciences (F.-C.H., J.D.)

8. Center for Neuroimaging, Indiana University School of Medicine, Indianapolis (K.N., S.L.R.)

9. Department of Neurology (E.H., R.S.)

10. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, United Kingdom (I.J.D., J.M.W., J.M.S., M.d.C.V.-H., M.E.B., N.A.R., S.P.H.)

11. Department of Neurology and Neurosurgery (P.A.N., R.F.G.)

12. Bordeaux Population Health Research Centre U1219, Inserm, France (A.M., G.C., S.D.)

13. Department of Epidemiology (C.M.v.D., H.H.H.A.)

14. Department of Biostatistics, Boston University School of Public Health, MA (A.S.B., A.L.D., Q.Y., S.L.)

15. Institute for Community Medicine (A.T.)

16. Department of Internal Medicine (B.I.F.)

17. Institute of Molecular Biology and Biochemistry (H.S., Y.S.), Medical University of Graz, Austria

18. Department of Medicine (D.M.B., L.R.Y., R.A.M.), Johns Hopkins School of Medicine, Baltimore, MD

19. Department of Radiology, Leiden University Medical Center, the Netherlands (M.A.v.B.)

20. Department of Medicine, The University of Vermont Larner College of Medicine, Burlington (M.C.)

21. Department of Diagnostic Medicine, Dell Medical School at The University of Texas at Austin (R.N.B.)

22. Departments of Radiology and Medical Informatics (W.J.N.)

23. Department of Medicine, The University of Mississippi School of Medicine, Jackson (W.J.N.)

24. Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (M.H.)

25. Department of Biochemistry (D.W.B., N.D.P.), Wake Forest School of Medicine, Winston-Salem, NC

26. Department of Epidemiology, The University of Alabama at Birmingham School of Public Health (C.E.L.)

27. Department of Neurology, UC Davis School of Medicine (C.S.D., P.M.), CA

28. Institute of Genetics and Functional Genomics, University of Greifswald, Germany (G.H.)

29. Institute for Diagnostic Radiology and Neuroradiology (S.L.)

30. Department of Biostatistics, University of Washington School of Public Health, Seattle (K.M.R.)

31. Department of Radiology, The University of Texas Southwestern Medical Center, Dallas (J.A.M.)

32. Division of Research, Kaiser Permanente Northern California, Oakland (S. Sidney)

33. Departments of Internal Medicine, Epidemiology, and Clinical Chemistry (A.G.U.)

34. Institute for Clinical Chemistry and Laboratory Medicine (M.N.)

35. Institute for Translational Genomics and Population Sciences, Harbor-UCLA Medical Center, Torrance, CA (J.I.R.)

36. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis (P.J.S.)

37. Human Genetics Center, The University of Texas Health Science Center at Houston School of Public Health (E.B.)

38. Neurodegeneratives Diseases Institute-CNRS UMR 5293 (B.M.), University of Bordeaux, France

39. Department of Neurology (B.v.S.)

40. Population Sciences Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (D.L.)

41. Departments of Radiology and Epidemiology (M.W.V.)

42. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (S.T.T.)

43. Departments of Epidemiology, Radiology and Neurology (M.A.I.), Erasmus University Medical Center, Rotterdam, the Netherlands

44. Department of Psychiatry and Psychotherapy (H.J.G.), University Medicine Greifswald, Germany

45. Departments of Neurology and Epidemiology (W.T.L.), University of Washington, Seattle, WA

46. Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD (L.J.L.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

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