Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling-Reference-Cited by-同舟云学术

Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling

Published:2024-08 Issue:8 Volume:55 Page:2139-2150
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Jeong Soomin¹²^ORCID,Chokkalla Anil K.¹^ORCID,Davis Charles K.¹^ORCID,Jeong Hyunmook³,Chelluboina Bharath¹^ORCID,Arruri Vijay¹,Kim Bori¹,Narman Ashlyn¹,Bathula Saivenkateshkomal¹,Arumugam Thiruma V.⁴^ORCID,Bendlin Barbara B.⁵,Vemuganti Raghu¹²⁶^ORCID

Affiliation:

1. Department of Neurological Surgery (S.J., A.K.C., C.K.D., B.C., V.A., B.K., A.N., S.B., R.V.), University of Wisconsin, Madison.

2. Neuroscience Training Program (S.J., R.V.), University of Wisconsin, Madison.

3. Department of Transdisciplinary Medicine, Institute of Convergence Medicine with Innovative Technology, Seoul National University Hospital, Seoul, South Korea (H.J.).

4. Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia (T.V.A.).

5. Department of Medicine (B.B.B.), University of Wisconsin, Madison.

6. William S. Middleton Veterans Hospital, Madison, WI (R.V.).

Abstract

BACKGROUND: Preconditioning by intermittent fasting is linked to improved cognition and motor function, and enhanced recovery after stroke. Although the duration of fasting was shown to elicit different levels of neuroprotection after ischemic stroke, the impact of time of fasting with respect to the circadian cycles remains unexplored. METHODS: Cohorts of mice were subjected to a daily 16-hour fast, either during the dark phase (active-phase intermittent fasting) or the light phase (inactive-phase intermittent fasting) or were fed ad libitum. Following a 6-week dietary regimen, mice were subjected to transient focal cerebral ischemia and underwent behavioral functional assessment. Brain samples were collected for RNA sequencing and histopathologic analyses. RESULTS: Active-phase intermittent fasting cohort exhibited better poststroke motor and cognitive recovery as well as reduced infarction, in contrast to inactive-phase intermittent fasting cohort, when compared with ad libitum cohort. In addition, protection of dendritic spine density/morphology and increased expression of postsynaptic density protein-95 were observed in the active-phase intermittent fasting. CONCLUSIONS: These findings indicate that the time of daily fasting is an important factor in inducing ischemic tolerance by intermittent fasting.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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