Affiliation:
1. the Departments of Clinical Physiology (J.P.T., E.A.L.), Clinical Nutrition (M.I.J.U.), Medicine (L.K.N.), and Clinical Radiology (K.P.L.P.), Kuopio University Hospital and University of Kuopio (Finland).
Abstract
Background and Purpose
Our aim was to determine the predictive factors for stroke in patients with non–insulin-dependent diabetes mellitus (NIDDM).
Methods
We studied 133 patients with NIDDM at the time of diagnosis and 5 and 10 years later.
Results
The number of new fatal or nonfatal strokes was 19 (14.7%; 14 after 5-year examination). High initial fasting blood glucose (odds ratio [OR], 1.2; 95% confidence interval [CI], 1.04 to 1.4) and the use of β-blocking agents (OR, 6.7; 95% CI, 2.1 to 21.5) at baseline and the presence of parasympathetic neuropathy (OR, 6.7; 95% CI, 1.5 to 29.9), or sympathetic autonomic nervous dysfunction (OR, 1.1; 95% CI, 1.01 to 1.2), hypertriglyceridemia (OR, 5.7; 95% CI, 1.1 to 31.0), or use of β-blocking agents (OR, 6.4; 95% CI, 1.3 to 31.2), and high fasting plasma glucose (OR, 1.2; 95% CI, 1.0 to 1.5) determined at 5-year examination predicted the development of stroke.
Conclusions
Autonomic neuropathy is an independent risk factor for stroke in NIDDM.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Cited by
75 articles.
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