Effects of Betahistine HCl, Nicotinic Acid, and Histamine on Basilar Blood Flow in Anesthetized Dogs-Reference-Cited by-同舟云学术

Effects of Betahistine HCl, Nicotinic Acid, and Histamine on Basilar Blood Flow in Anesthetized Dogs

Published:1971-07 Issue:4 Volume:2 Page:409-415
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

ANDERSON WESLEY D.¹,KUBICEK WILLIAM G.²

Affiliation:

1. Department of Anatomy, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota, 55455

2. Department of Physical Medicine and Rehabilitation, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota, 55455

Abstract

An intermandibular-transclival approach to the posterior cranial fossa has been developed which allows exposure of the basilar artery for attachment of a small electromagnetic blood flow transducer. The results of single intravenous injections of betahistine hydrochloride indicated a mean increase in basilar artery blood flow of 54% and a simultaneous decrease in systemic arterial blood pressure of a duration of action of approximately one minute. Histamine phosphate yielded results similar to betahistine hydrochloride, while nicotinic acid produced only slight increases in blood flow in the basilar artery.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.STR.2.4.409

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