Transcranial Doppler Sonography and Magnetic Resonance Angiography in the Assessment of Collateral Hemispheric Flow in Patients With Carotid Artery Disease

Abstract

Background and Purpose The aim of this investigation was to compare the respective efficacy of transcranial Doppler sonography (TCD) and magnetic resonance angiography (MRA) for the assessment of intracranial hemodynamics in patients with extracranial occlusion or severe stenosis of the internal carotid artery (ICA). Methods Twenty-five patients with unilateral ICA occlusion (n=20) or tight stenosis (n=5) demonstrated by duplex scanning or angiography were studied with both TCD and MRA. Three-dimensional time-of-flight MRA was used for the evaluation of extracranial-intracranial ICAs. Collateralization through the circle of Willis was investigated by means of selective two-dimensional MRA with presaturation of the carotid siphon, ophthalmic artery, or basilar artery. TCD was performed according to published standards: Anterior, middle, and posterior cerebral arteries were insonated through the temporal window, and carotid siphon and ophthalmic artery were assessed through a transorbital approach. Collateralization through the anterior circle of Willis was assumed if anterior cerebral artery flow was reversed, through the external carotid artery if ophthalmic artery flow was reversed, and through the basilar artery if the ratio of ipsilateral to contralateral posterior cerebral artery velocity was greater than 50%. TCD and MRA were performed by different investigators unaware of the results obtained with the other technique. Results In every case time-of-flight MRA demonstrated the ICA occlusion or stenosis. There was an excellent correlation (κ=0.64) between TCD and MRA in assessing the hemodynamic contribution of the anterior part of the circle of Willis, whereas MRA was unable to detect the anastomotic pathway of the ophthalmic artery (κ=0.32). The contribution of the posterior communicating artery was difficult to assess with both techniques, but in three cases only MRA showed unequivocal evidence of collateralization. In three cases of middle cerebral artery stenosis TCD was superior to MRA in demonstrating the patency of the vessel. Conclusions TCD and MRA should be considered complementary techniques. Combining the findings of both examinations may help to better understand the changes in intracranial hemodynamics produced by extracranial carotid occlusion. The contribution of the ophthalmic pathway, although important for the intraorbital structures, is probably of limited functional significance to the hemispheric blood supply.