Affiliation:
1. Department of Medicine and Geriatrics, Kochi Medical School, Nankoku City, Japan.
Abstract
Controversies exist whether incidental neuroradiological brain lesions in the elderly are associated with depressed neuropsychological function. To address this important issue in a cross-sectional study, we related brain lesions on magnetic resonance imaging to a variety of cognitive and neurobehavioral function tests in an independent, normal elderly population.
We studied 73 independent asymptomatic elderly individuals (mean +/- SD age 70 +/- 6 years) to determine the relations between degree of brain atrophy, location and number of "lacunes," and grade of periventricular hyperintense lesions with a variety of cognitive and neurobehavioral function scores.
We found that severity of neuroradiological changes increased while neuropsychological function scores declined with age. After adjustment for the effect of age, advanced periventricular hyperintensities, but not brain atrophy or patchy "lacunar" lesions, were associated with declines in all neuropsychological functions tested.
We conclude that incidental advanced periventricular diffuse or patchy white matter changes may play a role in the development of cognitive and neurobehavioral impairments in apparently normal elderly persons.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)
Reference25 articles.
1. Patchy periventricular white matter lesions in the elderly: A common observation during NMR imaging;Bradley WG;Noninv Med Imag,1984
2. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.
3. Periventricular lesions on MRI: Facts and theories;Chimowitz MI;Curr Concepts Cerebrovasc Dis Stroke,1989
4. Brain MRI: Pathologic correlation with gross and histopathology: 1. Lacunar infarction and Virchow-Robin spaces;Braffman BH;AJNR,1988
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