Impact of Thalamic Hematoma on Six-Month Mortality and Motor and Cognitive Functional Outcome

Abstract

Background and Purpose In this study we examined the functional outcome of thalamic hemorrhage after 6 months as it related to neurological and computed tomographic (CT) findings in 104 patients. Methods Level of consciousness was determined on admission. Extension and volume of hematoma were examined with CT within 3 days. After 6 months, motor function was evaluated using hemiplegic staging by the scale of Brunnström, and cognition was assessed by the Hasegawa dementia rating scale administered in Japanese. Results Twelve patients (12%) died from stroke after 6±6 days (mean±SD), which correlated with volume of hematomas ( P <.001), levels of consciousness ( P <.005), and miosis ( P <.01). Six patients (6%) died from systemic complications after 23±18 days, which correlated with age ( P <.05). Initially, 88 patients (85%) had hemiparesis, which persisted in 78 (75%) patients (18 deaths and 60 survivors). After 6 months, the Brunnström scale scores were lower in patients with hematomas extending to the internal capsule ( P <.01) than in those with hematomas localized within the thalamus, and scores were lowest in patients with hematomas extending to the midbrain or putamen ( P <.01). Motor function was well correlated with the extension and volume of hematomas ( P <.001) and with the consciousness level ( P <.001). Activities of daily living were correlated with hematoma extension and advanced age. Cognitive impairment was correlated with disturbance of consciousness ( P <.01) and ventricular extension of the hematoma ( P <.05) in 80 nonaphasic patients. Conclusions The extension and volume of hematomas, indicating direct cerebral damage, are useful indicators of mortality from thalamic hemorrhage, motor functional outcome, and level of activities of daily living after 6 months. The disturbance of consciousness and ventricular extension of the hematoma, suggesting diffuse brain damage, could be predictors of cognitive function.