Bioprosthetic Aortic Valve Thrombosis: Definitions, Clinical Impact, and Management: A State-of-the-Art Review

Author:

Chitturi Kalyan R.1ORCID,Aladin Amer I.1ORCID,Braun Ryan2,Al-Qaraghuli Abdullah K.1,Banerjee Avantika1,Reddy Pavan1ORCID,Merdler Ilan1,Chaturvedi Abhishek1ORCID,Abusnina Waiel1,Haberman Dan1,Lupu Lior1,Rodriguez-Weisson Fernando J.1,Case Brian C.1ORCID,Wermers Jason P.1ORCID,Ben-Dor Itsik1,Satler Lowell F.1,Waksman Ron1ORCID,Rogers Toby12ORCID

Affiliation:

1. Section of Interventional Cardiology, MedStar Washington Hospital Center, DC (K.R.C., A.I.A., A.K.A.-Q., A.B., P.R., I.M., A.C., W.A., D.H., L.L., F.J.R.-W., B.C.C., J.P.W., I.B.-D., L.F.S., R.W., T.R.).

2. Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (R.B., T.R.).

Abstract

Bioprosthetic aortic valve thrombosis is frequently detected after transcatheter and surgical aortic valve replacement due to advances in cardiac computed tomography angiography technology and standardized surveillance protocols in low-surgical-risk transcatheter aortic valve replacement trials. However, evidence is limited concerning whether subclinical leaflet thrombosis leads to clinical adverse events or premature structural valve deterioration. Furthermore, there may be net harm in the form of bleeding from aggressive antithrombotic treatment in patients with subclinical leaflet thrombosis. This review will discuss the incidence, mechanisms, diagnosis, and optimal management of bioprosthetic aortic valve thrombosis after transcatheter aortic valve replacement and bioprosthetic surgical aortic valve replacement.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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