Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study

Author:

Tang Gilbert H.L.1ORCID,Spencer Julianne2,Rogers Toby3ORCID,Grubb Kendra J.45ORCID,Gleason Patrick56ORCID,Gada Hemal7,Mahoney Paul8,Dauerman Harold L.9,Forrest John K.10ORCID,Reardon Michael J.11ORCID,Blanke Philipp12,Leipsic Jonathon A.12,Abdel-Wahab Mohamed13ORCID,Attizzani Guilherme F.14ORCID,Puri Rishi15ORCID,Caskey Michael16,Chung Christine J.17,Chen Ying-Hwa18ORCID,Dudek Dariusz19,Allen Keith B.20ORCID,Chhatriwalla Adnan K.20ORCID,Htun Wah Wah21ORCID,Blackman Daniel J.22ORCID,Tarantini Giuseppe23ORCID,Zhingre Sanchez Jorge2,Schwartz Greta2,Popma Jeffrey J.2,Sathananthan Janarthanan24

Affiliation:

1. Department of Cardiovascular Surgery, Mount Sinai Health System, New York (G.H.L.T.).

2. Structural Heart & Aortic, Medtronic, Mounds View, MN (J. Spencer, J.Z.S., G.S., J.J.P.).

3. Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC (T.R.).

4. Division of Cardiothoracic Surgery (K.J.G.), Emory University, Atlanta, GA.

5. Structural Heart and Valve Center (K.J.G., P.G.), Emory University, Atlanta, GA.

6. Division of Cardiology (P.G.), Emory University, Atlanta, GA.

7. University of Pittsburgh Medical Center Pinnacle Health, PA (H.G.).

8. Sentara Heart Hospital, Norfolk, VA (P.M.).

9. University of Vermont Larner College of Medicine, Burlington (H.L.D.).

10. Division of Cardiology, Yale School of Medicine, New Haven, CT (J.K.F.).

11. Department of Cardiovascular Surgery, Houston Methodist, TX (M.J.R.).

12. Center for Heart Valve Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, Canada (P.B., J.A.L.).

13. Heart Center Leipzig at University of Leipzig, Germany (M.A.-W.).

14. Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, OH (G.F.A.).

15. Cleveland Clinic, OH (R.P.).

16. Abrazo Arizona Heart Hospital, Phoenix (M.C.).

17. Division of Cardiology, University of Washington Medical Center, Seattle (C.J.C.).

18. Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taiwan (Y.-H.C.).

19. Jagiellonian University Medical College, Krakow, Poland (D.D.).

20. St. Luke’s Mid America Heart Institute, Kansas City, MO (K.B.A., A.K.C.).

21. Gundersen Health System, La Crosse, WI (W.W.H.).

22. Department of Cardiology, Leeds Teaching Hospitals, Leeds, United Kingdom (D.J.B.).

23. Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (G.T.).

24. Center for Heart Valve Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, Canada (J. Sathananthan).

Abstract

BACKGROUND: Coronary accessibility following redo–transcatheter aortic valve replacement (redo-TAVR) is increasingly important, particularly in younger low-risk patients. This study aimed to predict coronary accessibility after simulated Sapien-3 balloon-expandable valve implantation within an Evolut supra-annular, self-expanding valve using pre-TAVR computed tomography (CT) imaging. METHODS: A total of 219 pre-TAVR CT scans from the Evolut Low-Risk CT substudy were analyzed. Virtual Evolut and Sapien-3 valves were sized using CT-based diameters. Two initial Evolut implant depths were analyzed, 3 and 5 mm. Coronary accessibility was evaluated for 2 Sapien-3 in Evolut implant positions: Sapien-3 outflow at Evolut node 4 and Evolut node 5. RESULTS: With a 3-mm initial Evolut implant depth, suitable coronary access was predicted in 84% of patients with the Sapien-3 outflow at Evolut node 4, and in 31% of cases with the Sapien-3 outflow at Evolut node 5 ( P <0.001). Coronary accessibility improved with a 5-mm Evolut implant depth: 97% at node 4 and 65% at node 5 ( P <0.001). When comparing 3- to 5-mm Evolut implant depth, sinus sequestration was the lowest with Sapien-3 outflow at Evolut node 4 (13% versus 2%; P <0.001), and the highest at Evolut node 5 (61% versus 32%; P <0.001). CONCLUSIONS: Coronary accessibility after Sapien-3 in Evolut redo-TAVR relates to the initial Evolut implant depth, the Sapien-3 outflow position within the Evolut, and the native annular anatomy. This CT-based quantitative analysis may provide useful information to inform and refine individualized preprocedural CT planning of the initial TAVR and guide lifetime management for future coronary access after redo-TAVR. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02701283.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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