1. From the Program in Cardiovascular Research (S.B.O., S.H.E.Z., A.Y.L.C., B.M., M.R.), The Hospital for Sick Children, and Departments of Pediatrics (M.R.), Laboratory Medicine and Pathobiology (S.B.O., S.H.E.Z., M.R.), Medicine (M.R.), and Cardiovascular Surgery (S.B.O.), University of Toronto, Toronto, Ontario, Canada; and Institute for Molecular and Cellular Biology (Y.K.), Osaka University, Osaka, Japan.