1. From the Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan (A.H.-S., N.M., A.H., H.N., S.K., T.F., I.S.); Drug Metabolism and Pharmacokinetics Research Laboratories (K.N.) and R&D Planning Department (A.O.), Daiichi Sankyo Co, Ltd, Tokyo, Japan.