1. From the Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden (S.S., C.E., P.R., M.L., L.-M.G.); Department of Clinical and Molecular Medicine, Institution of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden (S.S., C.E., P.R., M.L., L.-M.G.); BioScience, AstraZeneca R&D, Mölndal, Sweden (L.-M.G.).