1. From the Departments of Medicine and Anesthesiology (J.E.H.-G., D.M.B., L.R.Y., D.V., L.C.B.) and Critical Care Medicine (N.F.), Johns Hopkins University School of Medicine, Baltimore, Md; Inherited Disease Research Branch (A.F.W.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Md; and the Department of Medicine (P.B.), Thomas Jefferson University Hospital, Philadelphia, Pa.