Evolution of the Arterial Structure and Function From Infancy to Adolescence Is related to Anthropometric and Blood Pressure Changes

Author:

Sarkola Taisto1,Manlhiot Cedric1,Slorach Cameron1,Bradley Timothy J.1,Hui Wei1,Mertens Luc1,Redington Andrew1,Jaeggi Edgar1

Affiliation:

1. From the Division of Cardiology, Labatt Family Heart Centre (T.S., C.M., C.S., T.J.B., W.H., L.M., A.R., E.J.); Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Canada (A.R., E.J.); and Children’s Hospital, University of Helsinki and Helsinki University Central Hospital, Finland (T.S.).

Abstract

Objective— To develop a normative data set and to study the relationship among arterial structure, different anthropometric measures, blood pressure, and arterial function during healthy childhood using very-high-resolution ultrasound (25–55 MHz). Methods and Results— In 135 healthy children between 0 and 18 years of age, we assessed the structure of the carotid arteries, larger peripheral arteries, aorta, and left ventricle with ultrasound. Arterial stiffness was assessed by pulse wave velocity and endothelial function by brachial flow-mediated dilation. Reference curves adjusted for age and body surface area of arterial lumen diameters, intima-media thickness, and adventitia thickness were developed. Arterial walls thicken during childhood predominantly as a result of a progressive increase in intima-media thickness. There were significant associations among lumen diameter ( R 2 range, 0.20–0.88 for different arteries; P <0.001), intima-media thickness ( R 2 range, 0.47–0.85; P <0.001), left ventricular mass ( R 2 =0.90; P <0.001), and adventitia thickness ( R 2 range, 0.15–0.22; P <0.001) with sex, age, body surface, and systolic blood pressure. Arterial wall stress was associated with lumen diameter ( R 2 range, 0.52–0.83; P <0.001) and intima-media thickness ( R 2 range, 0.53–0.88; P <0.001). Limited relationships were found among arterial wall layer thickness, stiffness, and endothelial function. Conclusion— In healthy children, the evolution of the arterial structure is mainly related to anthropometrics and blood pressure.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3