1. From the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY (B.C.M., A.H.-O., H.N.G.); Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA (B.S.); Department of Molecular and Medical Pharmacology (H.W.) and Institute for Molecular Medicine (H.W.), David Geffen School of Medicine, University of California, Los Angeles, CA.