1. From the Division of Cell and Molecular Biology (T.A., A.M.S., M.A.M., M.H.), Toronto General Hospital Research Institute; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research (S.H., M.H.) and the Departments of Medicine (M.H.) and Physiology (S.G., S.H., M.H.), University of Toronto, Ontario, Canada.