COVID-19 and the Heart and Vasculature-Reference-Cited by-同舟云学术

COVID-19 and the Heart and Vasculature

Published:2020-09 Issue:9 Volume:40 Page:2045-2053
ISSN:1079-5642
Container-title:Arteriosclerosis, Thrombosis, and Vascular Biology
language:en
Short-container-title:ATVB

Author:

Kadosh Bernard S.¹,Garshick Michael S.¹,Gaztanaga Juan²,Moore Kathryn J.¹,Newman Jonathan D.¹,Pillinger Michael³⁴,Ramasamy Ravichandran¹,Reynolds Harmony R.¹,Shah Binita⁴,Hochman Judith¹,Fishman Glenn I.¹,Katz Stuart D.¹

Affiliation:

1. From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.)

2. Division of Internal Medicine, Department of Cardiology, NYU Winthrop Hospital, Mineola (J.G.)

3. Department of Medicine, Division of Rheumatology, New York, NY (M.P.)

4. VA New York Harbor Healthcare System, Department of Medicine (M.P., B.S.).

Abstract

The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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