1. From the Research Unit, Division of Internal Medicine (I.B., K.D., M.D., L.Z., R.H., E.J.B., E.H.) and Department of Dermatology (E.C.), University Hospital of Zurich, Zurich, Switzerland; Growth and Development Biozentrum, University of Basel, Basel, Switzerland (V.A., A.H., M.N.H.); and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland (R.H., E.J.B.).