1. From the Department of Geriatrics and Vascular Medicine (Y.A., A.K., and K.S.), Tokyo Medical and Dental University, Tokyo, Japan; Life Science and Bioethics Research Center (A.K., M.O., and M.Y.), Tokyo Medical and Dental University, Tokyo, Japan; WPI Immunology Frontier Research Center (S.U. and S.A.), Osaka University, Osaka, Japan; and the Department of Nutrition (F.M.S.), Harvard School of Public Health, Boston, Mass.