1. From the Department of Clinical and Medical Therapy, Unit of Medical Therapy (M.A., B.C., A.M., F.C.), the Department of the Heart and Great Vessels Attilio Reale (F.B., G.T., C.G.), the Department of Experimental Medicine (P.P., R.V., A.V., F.V.), and Research Center for Clinical Trials (CRISC) (R.V., A.V.), La Sapienza University, Rome, Italy.