1. From the Division of Cardiology, Emory University, Atlanta, GA (M.S.M., S.A.F., L.L., A.V., H.E.L., Y.B., A.R., A.A.Q.); Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (Y.I.); Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (W.C., D.G.H.).