1. From the Lillehei Heart Institute (X.H., X.X., P.Z., H.G., Z.L., J.F., R.J.B., Y.C.) and Cardiovascular Division (X.H., X.X., P.Z., H.G., Z.L., J.F., R.J.B., Y.C.), University of Minnesota Medical School, Minneapolis, MN; Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg, Eppendorf, Germany (D.A., E.S., R.H.B.).