Saturated Fatty Acids and Inflammation: Who Pays the Toll?
Author:
Affiliation:
1. From the Divisions of Metabolism, Endocrinology and Nutrition (A.C.) and Cardiology (F.K.), Diabetes and Obesity Center of Excellence, University of Washington, Seattle.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Link
https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.110.203984
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1. Obesity is associated with macrophage accumulation in adipose tissue
2. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
3. TLR4 links innate immunity and fatty acid–induced insulin resistance
4. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
5. Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
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