1. From the Departments of Clinical Cell Biology (K.O., Y.S.) and Genome Research and Clinical Application (H.B., M.J.), Chiba University Graduate School of Medicine, Chiba, Japan; Kowa Research Institute (H.Y.), Kowa Co Ltd, Higashimurayama, Japan; Department of Medical Biochemistry (W.J.S.), Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.