1. From the Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine (P.W.B., N.S., S.N., A.N., M.O.T., I.R., S.D.V.) and The Wellcome Trust Centre for Human Genetics (C.P., B.D.), University of Oxford, Oxford, United Kingdom; and Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom (K.L., G.B.-G.).