1. From the Division of Cardiovascular Medicine, Department of Internal Medicine (K.N., T.Y., T.K., M.T., N.S., K.K., M.S., Y.R., T.I., M.Y., K.H.), Division of Signal Transduction, Department of Biochemistry and Molecular Biology (Y.R.), Kobe University Graduate School of Medicine, Kobe, Japan, Department of Experimental Pathology, Institute for Frontier Medical Science (N.S.), Kyoto University, Kyoto, Japan, and Hyogo Brain and Heart Center (M.Y.), Himegli, Japan.