Affiliation:
1. INSERM U1148 Laboratory for Vascular Translational Science Université de Paris and Université Sorbonne Paris Nord Paris France
2. Service de Physiologie Clinique Explorations Fonctionnelles AP‐HP Hôpital Lariboisière–F Widal Paris France
3. UMR‐S U1237 “Physiopathology and Imaging of Neurological Disorders,” Centre CYCERON Caen France
4. Département de Neuroradiologie Interventionnelle de la Fondation Rothschild et Département de Neurologie Hôpital Lariboisière Paris France
Abstract
Background
During the past few decades, several pathophysiological processes contributing to intracranial aneurysm (IA) rupture have been identified, including irregular IA shape, altered hemodynamic stress within the IA, and vessel wall inflammation. The use of preclinical models of IA and imaging tools is paramount to better understand the underlying disease mechanisms.
Methods
We used 2 established mouse models of IA, and we analyzed the progression of the IA by magnetic resonance imaging, transcranial Doppler, and histology.
Results
In both models of IA, we observed, by transcranial Doppler, a significant decrease of the blood velocities and wall shear stress of the internal carotid arteries. We also observed the formation of tortuous arteries in both models that were correlated with the presence of an aneurysm as confirmed by magnetic resonance imaging and histology. A high grade of tortuosity is associated with a significant decrease of the mean blood flow velocities and a greater artery dilation.
Conclusions
Transcranial Doppler is a robust and convenient imaging method to evaluate the progression of IA. Detection of decreased blood flow velocities and increased tortuosity can be used as reliable indicators of IA.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
1 articles.
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